10 Oct 2019 - 11 Oct 2019 | Zürich, Switzerland

Agenda

Thursday
10 Oct 2019
08:00 – 09:00
USZ OST GROSSER HOER B10
Registration
  • Badge pick-up 
  • Onsite registrations
08:20 – 08:50
USZ Foyer OST, Cafeteria Dick&Davy
Matchmaking: one-to-one meetings

Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

Matchmaking
09:00 – 09:30
USZ OST GROSSER HOER B10
Opening and Introduction

  • Welcome from the Organizers
  • Agenda and Goals of the Conference
  • Opening by Prof Dr Gregor Zünd, Director of the USZ board, CH
09:30 – 10:50
USZ OST GROSSER HOER B10
Scientific Section 1
  • Keynote: Guillaume Canaud (Necker Hospital Paris, FR)

Targeted therapy in patient with PIK3CA related overgrowth syndrome.

CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related overgrowth syndromes (PROS). This rare condition has no specific treatment and a poor survival rate.  On the basis of studies in postnatal mouse models, BYL719, an inhibitor of PIK3CA, was used to treat nineteen patients with PROS. The drug improved the disease symptoms in all patients. The treatment was not associated with any substantial side effects. This study provides the first direct evidence supporting PIK3CA inhibition as a promising therapeutic strategy in patients with PROS.

 

  • Science Pitches
  1. Nako NakatsukaUnderstanding Neuronal Communication using DNA Aptamer Bioelectronics.
  2. Horea Christian -  Publishing Reproducible Results in Reexecutable Documents.
  3. Elisabeth Fejér  Evaluation of a Mandibular Canal Classification System to Predict the Incidence of Postoperative Complications Following Third Molar Removal.
            Scientific Session
            10:50 – 11:00
            USZ OST GROSSER HOER B10
            PIs of Tomorrow Pitch

            Elisa Araldi, chair of the Life Science Switzerland (LS2) annual meeting PIs of Tomorrow (PIOT) session, CH

            If you want to start an academic career in Switzerland, the LS2 PIOT session (Zurich February 13-14, 2020) is a great opportunity to showcase your past work and future project plans, and to get valuable feedback on your job interview talk from a knowledgeable jury of professors. - The PIOT session is one of the most attended session of the LS2 meeting, and most of the past winners now hold positions as group leaders!

            11:00 – 11:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Coffee Break
            11:00 – 11:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Matchmaking: one-to-one meetings

            Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

            Matchmaking
            11:30 – 12:30
            USZ OST GROSSER HOER B10
            Scientific Section 2
            • Science Pitches
            1. Karin Meier Metabolic landscape of the mammalian digestive tract.
            2. Augusto Martins LimaA novel “bleeding-free” antiplatelet drug to treat thrombosis.
            3. Daria Glushkina - Physiologically-based toxicokinetic models to assess TCDD transfer from feed into edible tissues of pigs.
            4. Giada Ingoglia - Heme-Nrf2 signaling triggers macrophage hypoinflammation conferring disease tolerance to macrophage-driven inflammatory disease in acute hemolysis.
            5. Lafi AldakakThe Relationship between Autoimmune Diseases and Protection against Infections.
            6. Flavia CamponovoModelling and simulations to investigate alternative use of vaccines for malaria control, elimination and prevention of resurgence.
            Scientific Session
            12:30 – 13:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Lunch Break
            Lunch
            12:30 – 13:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Matchmaking: one-to-one meetings over Lunch

            Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

            Matchmaking
            13:30 – 14:30
            USZ OST GROSSER HOER B10
            Topic 1: Postdoc Funding in Science - How to apply for money

            by Sabine Werner (Professor at the Institute for Molecular Health Sciences, ETH Zürich, & member of the foundation council and executive committee of the SNF, CH)

            co-leads:  Alexandra Zingg (Project Manager EU GrantsAccess office ETHZ, CH) & Joao Matos (Assistant Professor ETHZ, CH)

            What is the best path to transition from a postdoc to become an independent researcher? What are the different funding agencies that one can apply to? What is the best moment to start applying for funding? In this workshop we will try to answer those questions and get the different points of view of people that have successfully perform this transition and helped others to achieve it. Join this session if you are curious about what does it take to successfully bring your own research idea to the next level.

            Parallel Sessions
            13:30 – 14:30
            USZ OST KLEINER HOER B5
            Topic 2: Career Transitions - How to find your map

            by Verity Elston (Head of Careers Advice for the Graduate Campus UNIL & Director of Portfolio Formation, Lausanne, CH)

            With so few tenure track academic positions on the market, many postdoctoral researchers consider other career paths. Join this session if you are curious about how one makes the transition from an academic position into a career outside of academia. We will explore what resources and strategies are available to you to support this transition.

            This session is limited to 25 participants. Registration is on a first come, first serve basis.

            Parallel Sessions
            14:30 – 16:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Matchmaking: one-to-one meetings

            Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

            Matchmaking
            14:30 – 16:30
            USZ Foyer OST, Cafeteria Dick&Davy
            Poster Session

            POSTER PRESENTATION GUIDELINES HERE.

            Please no photography or posting of unpublished content on social media unless you obtain the explicit permission of the presenter.

            Scientific Session
            16:30 – 17:30
            USZ OST KLEINER HOER B5
            Topic 3: Open Science Culture – Science for all, by all

            by Wen Hwa Lee (Chief Executive Officer at Action Against AMD & Programme Director of the Oxford Martin Programme on Affordable Medicines)

            co-leads: 

            Markus Köster (Director, Corporate Department Research Coordination at Boehringer Ingelheim, DE) 

            Leila Alexander (COO, Personalized Health Informatics Group at the Swiss Institute of Bioinformatics, CH)


            Open Science Culture – Science for all, by all

            Most of the biggest challenges we face today can’t be solved by isolated groups of very specialised scientists and their knowledge. It is thus imperative that we start exploring how to bring together the many experts to create knowledge which is much bigger than the sum of its parts – the path to breakthrough innovation.

            One of the most effective way to achieve this next level of hyper-connection is to start sharing real, high-quality research tools and platforms, where anyone can get free or equitable access to co-create with colleagues from all disciplines and sectors.

            We will be running three parallel workshops (limited seats!) using Open Science resources which are available right now, including drug discovery compounds, datasets for AI, data sciences and personalised medicine in UK and Switzerland.

              Parallel Sessions
              16:30 – 17:30
              USZ OST GROSSER HOER B10
              Topic 4: Gender Equality

              panel discussion:

              • Eleonore Lépinard (Associate Professor at Institute for Social Sciences and Centre for Gender Studies UNIL, CH)
              • Simona Isler (Equal Opportunity Commissioner for SNFS, CH)
              • Johannes Bohacek (Professor at the Department of Health Sciences and Technology ETHZ, CH)
              • Moderator: Mirko Santello (Editor at Frontiers, Lausanne, CH)
              Parallel Sessions
              17:45 – 18:45
              USZ OST GROSSER HOER B10
              Scientific Section 3
              • Keynote: Antonia Maria Müller (USZ, CH)

              Translating cellular therapies from the bench to the bedside.

              In this talk it will be exemplified how crucial preclinical laboratory studies were and continue to be for the improvement of existing hematopoietic cell therapies and the development of innovative strategies such as chimeric antigen-receptor T cell therapies. Cellular therapies are one prime example of true translational innovation reaching and shaping today’s everyday care.

              Scientific Session
              18:45 – 19:00
              USZ OST GROSSER HOER B10
              Closing Remarks and Poster Prize

              Best Poster and Science Pitch will receive a prize sponsored by Roche and ETH PACE respectively. 

              19:00 – 20:00
              USZ Foyer OST, Cafeteria Dick&Davy
              Networking Apéro
              Friday
              11 Oct 2019
              08:00 – 09:00
              USZ OST GROSSER HOER B10
              Registration
              • Badge pick-up 
              • Onsite registrations
              08:20 – 08:50
              USZ OST KLEINER HOER B5
              Matchmaking: one-to-one meetings

              Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

              Matchmaking
              09:00 – 09:30
              USZ OST GROSSER HOER B10
              Opening and Information
              • Opening by Prof. Dr. Michael Schaepman, Vice President Research at University of Zurich
              • Information by the organizers
              09:30 – 11:15
              USZ OST GROSSER HOER B10
              Section 1: Open Science and Evaluation of Scientific Research, Part 1
              • Keynote: Lawrence Rajendran (Founder of Science Matters; van Geest Professor of Dementia Research, Deputy Director, UK Dementia Research Institute, King’s College London Centre, UK)

              Open and reproducible Science - the ScienceMatters way.

              There is a serious crisis in current models of science publishing: Irreproducibility, non-communication and blocked access of scientific data. One of the important reasons for this crisis is the pressure and demand for full story-based, positive scientific studies to be considered for publication in most of the journals. The agony and the anxiety to get the studies in limited space in these journals combined with the unfair incentives of a “Publish or Perish” culture breed dishonesty that gives rise to irreproducibility in science. During this tortuous process, many scientific observations remain unpublished either because of the inability to develop them into the “stories” including negative data, confirmatory data or observations that are not “sexy” enough. Estimates are that less than 1% of researchers publish more than one paper a year. This suggests that most of the scientific observations made with taxpayers’ funds are never communicated to find place in scholarly space. We would like to change this fundamentally.

              We have created ScienceMatters (www.sciencematters.io) is the first platform for scientists to publish single observations and not fully developed stories. By eliminating the need to tell full stories, and favoring simple data-based observations over story-telling, we eliminate the current pressure to tell sexy stories. Scientists can publish single and robustly validated observations, be it orphan, negative, confirmatory, contradicting after the observations are vetted through triple-blind peer-review and all the peer review reports are published along with the papers. This also reduces the negative incentives associated with publishing in high-impact journals, namely to come up with data that must fit the big storyline, since it is this narrative pressure that in some unfortunate cases can lead to fraudulence. Therefore, ScienceMatters brings honesty and speed to scientific publishing and helps the science community to produce robust and better results. The platform is open access and allows scientists to get the unique opportunity to publish peer-reviewed single observations with the integration of cutting-edge social media features, thus engaging the community to provide post-publication review both by the experts and other scientists/readers. The platform has the possibility of being a one-stop source for rapid dissemination of honest and scientifically valid observations or data on replication, thereby enabling the natural emergence of the honest scientific narrative as opposed to the pruned narrative of data, as it is done currently. 

              • panel discussion: 
                • Merja Hoppe (Research Services at the ETH Library, CH)
                • Tania Jenkins (Scientific officer at SCNAT, CH)
                • Bernd Pulverer (Chief Editor The EMBO Journal; Head at EMBOPress, DE)
                • Moderator: Wen Hwa Lee (Chief Executive Officer at Action Against AMD & Programme Director of the Oxford Martin Programme on Affordable Medicines, UK)
              Scientific Session
              11:15 – 11:45
              USZ Foyer OST, Cafeteria Dick&Davy
              Coffee Break
              11:15 – 11:45
              USZ OST KLEINER HOER B5
              Matchmaking: one-to-one meetings

              Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

              Matchmaking
              12:00 – 13:45
              USZ OST GROSSER HOER B10
              Section 1: Open Science and Evaluation of Scientific Research, Part 2
              • Keynote: Stephen Curry (DORA and Imperial College, London)

              The Declaration on Research Assessment (DORA): Opening up the measure of success.
              We seem to have spent the last twenty years on the threshold of the open access “revolution". Though tremendous progress has been made, we have yet to realise all the potential that digital technology appeared to offer at the outset of the 21st Century. Part of the difficulty is that the scholarly community has become entangled by the metricisation of research assessment. Unpicking this knotty problem is the task that DORA – among others – has set itself. But it is not enough just to expose the problem. We have to focus on providing solutions that work for science and for society at large. 

              • panel discussion: 
                • Merja Hoppe (Research Services at the ETH Library, CH)
                • Tania Jenkins (Scientific officer at SCNAT, CH)
                • Bernd Pulverer (Chief Editor The EMBO Journal; Head at EMBOPress, DE)
                • Moderator: Leila Alexander (COO, Personalized Health Informatics Group at the Swiss Institute of Bioinformatics, CH)
                Scientific Session
                13:45 – 14:00
                Insights into the UZH Entrepreneur Fellowship

                Maria Olivares (Head UZH Innovation, Zurich, CH)

                Prajwal Prajwal (UZH Entrepreneurship Fellow, Co-Founder Clemedi, Institute of Laboratory Animal Science, Schlieren, CH)


                14:00 – 15:00
                USZ OST KLEINER HOER B5
                Lunch Break
                Lunch
                14:00 – 15:00
                USZ OST KLEINER HOER B5
                Matchmaking: one-to-one meetings

                Select this session when you want to be available for or schedule one-to-one meetings with other meeting participants.

                Matchmaking
                15:00 – 15:15
                USZ OST GROSSER HOER B10
                Company Talk: WYSS ZURICH
                15:15 – 17:15
                USZ OST GROSSER HOER B10
                Section 2: Ethics and Challenges in Precision Medicine
                • Keynote: Jeanette McCarthy (Adjunct Associate Professor at UCSF and Department of Community and Family Medicine at Duke University, USA, & Founder of Precision Medicine Advisors)

                Genetic Testing: Past, Present and Future
                Most people think of the genome as static, but while your DNA doesn’t change, our knowledge about the relationship between your genetic variation and disease does. It was only in the 1990’s when the first genes for hereditary cancers were discovered and 2005 when the first genome-wide association study for common diseases bore fruit. Genetic testing really began taking off in 2013 and continues to expand as we unravel the genetic basis of disease. Big changes have occurred even in the last five years as we hone in on new genes, revise risk estimates associated with genetic variants and develop new applications, some of which are already being used in the clinic. In this presentation, you’ll learn about the state of the art in genetic testing: where we’ve been, where we’re at and where we're going. 

                • panel discussion: 
                  • Stephan Beck (Professor of Medical Genomics, UCL Cancer Institute, UK, & founding member of the Personal Genome Project, UK)
                  • Ulrike Held (Head of Scientific Methods Consulting at the Epidemiology, Biostatistics and Prevention Institute University of Zurich, CH)
                  • Susanne Driessen (Chair of the Executive Board of the Swiss Ethics Committees on research involving humans, CH)
                  • Sonali Quantius (Director Computational Biology at GSK, UK)
                  • Moderator - Paolo Cinelli (Head of Research of Clinic for Trauma Surgery at Center for Clinical Research USZ, CH)
                Scientific Session
                17:15 – 17:30
                USZ OST GROSSER HOER B10
                Closing Remarks
                • Closing remarks on conference by organisers
                  17:30 – 19:00
                  USZ Foyer OST, Cafeteria Dick&Davy
                  Networking Apéro
                  The event agenda's time zone is CEST.